Idera Pharmaceuticals Presents Data in Preclinical Models of Lymphoma on IMO-4200, a Dual Agonist of TLRs 7 and 8, at the American Society for Hematology Meeting



Idera Pharmaceuticals (Nasdaq:IDRA) announced that it presented new data showing that IMO-4200, a dual agonist of Toll-like receptor (TLR) 7 and TLR8, in combination with approved cancer treatments increased antitumor activity in preclinical models of lymphoma. The presentation by Idera scientists, entitled “IMO-4200, a novel TLR7 and TLR8 dual agonist, enhances antitumor effect of ofatumumab, rituximab and cytotoxics in preclinical models of hematological malignancies”, abstract number 3724, was made at the 53rd annual meeting of the American Society for Hematology being held in San Diego, California December 11-13, 2011.

“The data presented show that IMO-4200 provides a novel scientific rationale for the targeted immunotherapy of hematological malignancies,” said Nicola La Monica, Ph.D., VP of Biology of Idera Pharmaceuticals. “IMO-4200 has shown to potentiate the anti-cancer activity of a broad range of approved agents, including rituximab, bortezomib and ofatumumab, in preclinical models of lymphoma.”

IMO-4200 is a novel synthetic RNA-based dual agonist of TLR7 and TLR8 identified as a lead drug candidate for the treatment of hematological malignancies. IMO-4200 is designed to stimulate immune responses mediated through TLR7 and TLR8, which are expressed in human dendritic cells, B-cells, monocytes, and macrophages. In preclinical mouse models of cancer, IMO-4200 has shown anticancer activity involving both innate and adaptive immune responses. IMO-4200, when administered in combination with approved cancer therapy drugs, rituximab, ofatumumab or bortezomib, showed significantly increased antitumor activity compared to the single-agent effects in several preclinical lymphoma models.

Idera Pharmaceuticals applies its proprietary Toll-like Receptor (TLR) drug discovery platform to create immunomodulatory drug candidates. The Company's TLR-targeted candidates are being developed to treat autoimmune and inflammatory diseases, cancer, and for use as vaccine adjuvants. Additionally, the Company is advancing its gene-silencing oligonucleotide (GSO) technology for the purpose of inhibiting the expression of disease-promoting genes.

More about IDRA at www.iderapharma.com.

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